I haven't had a problem with the USB drivers getting lost lately, but for some reason I used to. Sometimes unplugging the devices would work, other times, I had to reboot Windows.
If you had the RTL AGC and tuner AGC buttons unchecked, did you try moving the tuner gain slider up from 0?
If you had the RTL AGC and tuner AGC buttons unchecked, did you try moving the tuner gain slider up from 0?