Well I played single player for about 45 mins last night (all I could sneak in without totally pissing off the girlfriend). It is great. Very enjoyable and amazing graphics. At first I was worried about the game control being sluggish, but then realized that you start the game injured so it is supposed to be like that. After you get to the "flashback" you have the same fluid controls as Uncharted 1. Looks to be a very good game! Can't wait until I have some more time to play this one (and try out the multiplayer).
I had the same concern at the beginning before I also realized that Drake was hurt... On Chapter 23 now and so far all I can say is it is far and away the best game I have ever played. My wife has been just sitting and watching me play it for about 6 hours in the last few days, and she NEVER does that.
I only have one minor complaint, which is that a couple of times I've been in close quarters (next to a wall, climbing or something) and the camera gets a little jinky, but it's not enough to even be annoying, let alone taking anything away from the game experience...