I think FOX cancelled the show due to viewr complaints about the show's content. It's a known fact that there's one episode which FOX refused to air ("Once Upon A Weinstein"). The new Season 3 DVD, which just came out this past Tuesday, includes that episode. Cartoon Network has plans to air that episode, but not until November. I don't know if TBS Superstation would air the episode on a weekday afternoon?
What hooked me to the show initally is the fact that the show is set in southern New England (Rhode Island) and references to this area are made every so often (such as the "Stop & Shop" supermarket, NECCO wafers and the football fans at each other's throats about the Jets and Patriots).
Now how do we get Seth McFarlane (Peter, Stewie and Brian), Alex Borstein (Lois), Seth Green (Chris) and Mila Kunis (Meg) all back together again?