My Harmonies (One & 650) work perfectly. I'm thinking about putting an IR blaster on Hopper #2, with the IR receiver at my kids computer/tv. Hopefully the blaster will block signals from affecting Hopper #1. Can't hurt to try. I've got plenty of RG6 and HDMI, so I can play around with both combinations and see if it'll work. The HDTV's are technically in a separate room, but the two rooms open on each other, no wall dividing. I'd still like both Hoppers in my main equipment rack, but if not, no biggie.
Harmony is fast on the updates....often faster than the device mfr.