Hey It's been about a year since this has been hashed out, so I thought I would bring it up again. I'm running Microsoft Security Essentials in conjunction with Threatfire and Malware Bytes on a 64-bit Windows 7 laptop. I haven't had any problems viruses but want to know other folks' opinions about the most effective anti-virus/anti-malware programs out there. It doesn't matter if they are free or not but it's hard to argue with good, free software.