Really depends on the device. Some USB powered ext 2.5" drives I have tried work with a single USB connection... (WD Passport for example).. Others I have tried require a double USB connection to power them. Some work on powered Hubs, some don't.. I have even seen some work on the rear USB connections on the computer and not on the front ones.
It doesn't make alot of sense to get anything less than 500gb for the 622 external HD feature since they are under $100 now, since you get 5-10gb/hour storage rates.
Plus alot of the 2.5 drives are 5400rpm, have been reported to not function well with the 622, since they probably only have a 2mb buffer as well.