But what make is your AMD 4600?
I have loaded this on my 3 AMD PCs here at the house (via Windows Update) and they are running perfect. All of mine are custom built AMDs. So strike a blow against this being simply an AMD issue.
I left off the X2 parts, it is an Athlon 64 4600+ X2. I built the computer myself and updated from the full XP service pack 3 CD I burned. I don't know if it is an AMD issue, a motherboard issue or even a driver problem, I am using this PC as a SageTV client and the audio problem made it unusable for my needs and I didn't feel like wasting my time troubleshooting the problem when it worked just fine running XP service pack 2.