It doesn't have a chance, but I'm going to nominate the new Xbox 360 Dashboard. With the deeper Kinect integration and inclusion of Kinect-compatible apps, I've watched over 30 episodes of Arrested Development on Netflix in the last week and a half and I've only touched an Xbox controller to turn the unit on. Everything else with voice and gestures and in a very natural way.
"Xbox, Next Episode"
Easily the nicest upgrade/compliment to my home theater this year, just barely edging out the DirecTV HD UI for me.
Kinect itself could end up being the next big thing for non-gamers next year as MS works to have the tech included in TVs.