You said you had four locations throughout your house and are getting a 522. If you have four different people that want to watch four different channels, you might want to have a 322 installed alongside the 522. You'd then have four independent tuners (two with the 522 and two with the 322). The 322 will cost you an extra $5 per month however, but you get the unit itself for free as a new customer. I don't know what (if anything) it would cost to add a 322 later, but if you don't have more than two people watching TV this would be way overkill in the first place. Consider a 322 as a 522 without DVR capabilities.
Using the existing cable wiring you describe in your house, any of the four TV's could be hooked up to access any of the four tuners (so the normal 322 users could in fact access the 522). That's what I just hooked up at my place. Well, my 3 upstairs TV's can only get at three of the tuners - but I plan to try hooking up the fourth later today. There is some possibility of chan3 vs. chan 4 interference, but I'll see if that actually plays out this evening.
If you only go with the 522, I would suggest taking it's two outputs (one on chan 3 or 4 and the other much higher - like chan 73) and "combining" them with a splitter used backwards before plugging that into your existing house cabling. That way all TV's hooked up to the house cabling can access either of the 522 tuners. That may be handy at times. You will have to move remote controls around from room to room to have control however, and possibly buy an RF/IR "remote extender" also. You might need an inline amp depending on how many splitters you actually end up with and how long your cable runs are. Cost $10 - $15 for a cheapo amp. I ended up with a "distribution amp" (an amp with four outputs) and that was $16.99 at BestBuy. My cabling is different than yours, and you shouldn't need a multi-output amp, or maybe no amp at all. The added benefit of a setup like this is fairly minimal, but if all's it's going to cost you is a splitter (which the installer will probably give you for free) ... why not?