I saved the old NFL announcer schedules from DBSForums, and I found some significant games that Charlie Jones called.
1983: Bills win first game at Orange Bowl since the 1960s
First playoff game in Seahawks history
1988: Seahawks clinch AFC West division title with a 43-37 shootout win over the L.A. Raiders
Cleveland's thrilling AFC Divisional Playoff win over the Bills in January 1990
1990: In Jerry Glanville's first game as Falcons coach, Atlanta blows out the Oilers
Lots of significant games in 1992:
Undefeated Dolphins lose to Colts; Steve Emtman return INT for TD
Broncos down 19-6 to the Chiefs with less than four minutes left. One guess as to who won the game?
Bill Cowher's first game (and win) as Steelers coach, over the Oilers in Houston
Brett Favre's first start in his legendary ironman streak against the Steelers
1993: Bills/Oilers: Comeback of Comebacks
1993: Bills beat Raiders in HORRIFIC weather conditions
1995: Raiders first game in Oakland since 1981
1995: First win in Carolina Panthers history over the Jets
1995: Final home game for the old Cleveland Browns before they became the Ravens
1996: New York Jets' only win in a 1-15 season
Also, on the college side:
Notre Dame/Florida State 'Game of the Century'