Here's my info:
I set up my HR22 on "Native off", Grey Pillar Bars (for a little "peace of mind" for my 50" Plasma TV burn-in safety), and I set up the Resolution to 1080i .
After setting it up this way on some recommendations here, it's worked well for me. I like the benefit of the channel-switching speed (faster) with Native turned off. Plus, I like how the HR22 handles switching from 16:9 channel material to 1.33:1 with this setup.