Sounds like a com error, possibly a bad cable, connector, corrupted loader software or satellite list.
Using a blue or a black color USB/Serial Converter? Blue color converter uses the provided Serial RS-232 null cable. The Black color converter is a direct connect null without using the separate Rs-232 null cable.
Is Editor / Loader version 1.8 in a folder without any other legacy library .dll files? If so, delete and reinstall.
Try deleting the current 1.8 software and unzip a new file. Install in a new folder with no other files.
Uninstall the Prolific USB/Serial converter device and driver, remove USB/Serial Converter. Reboot the computer and insert the USB/Serial converter. Install the device and driver from the cd (KE4EST or I will provide).
Sounds like you may have a recent Satellite List? If so, drive the actuator to 0000 position and perform a Global Reset, then power cycle the ASC1. Read the saved Satellite List to Editor/Loader 1.8, then write to the ASC1. Power cycle the ASC1 and it will drive to satellite position #1. Attempt to read the Satellite List from the ASC1 to Editor/Loader 1.8. Let me know if it is successful.