I'm unclear from both of your posts what cables you already have run. Does your OTA cable pass through your bedroom on its way to the 622, or does it go directly to the 622 and you have another single cable from the 622 to the bedroom TV? How is the sat. cable run, through the bedroom or directly to the 622? Is that a separate cable or have you already diplexed the OTA and sat signals into a single downfeed? (I assume you're using separate cables for sat and OTA since you have the preamp, but the question is where they run.)
If the OTA and sat cables are separate and both are run to the 622's location then you would only need a single cable back to TV2 and two splitter/combiners at the 622 end, one to split the OTA signal (after the power supply) to the 622's OTA input and a second to combine that split OTA signal with the 622's "agile" modulated output (channel range 21-69) into the cable to TV2.
(EDIT: I think the above will work, but I haven't tried it. One possible problem would be feeding the strong agile modulated output back into the 622's OTA input. It will already be attenuated by at least 7dB due to the splitter/combiners, but that may still be too strong and overload the tuner. If that's the case there are workarounds, like using a trap in the cable between the two splitter/combiners, and/or perhaps using the "cable" mode if your TV2 can accept those channels.)
You shouldn't need a splitter at the TV2 end. Both the TV1/2 signals from the 622 and the OTA signals would feed to your TV2's RF (antenna) tuner input. You would simply tune the OTA channels with TV2's tuner on their actual channels and the TV1/2 output from the 622 on whatever channels you set up in the 622. Note that you need to choose those agile output channels from the 622 to be in a range that would not coincide/interfer with any of your OTA channels.
(EDIT: If you need /choose to use the cable mode for the 622's agile output then you will need to split the signal to both the RF and cable tuner inputs at TV2.)
FWIW, there are potential issues with "retransmitting" the 622's modulated output back out your OTA antenna, but your preamp is unidirectional so that's won't be a problem in your installation. Check the FCC compliance section of your 622's user manual for more information.
If what I have here is accurate, then you would need only those 2 spliter/combiners at the 622's location with their inherent 3.5dB each attenuation, but your split/combined signals will likely be strong enough. You could add a VHF/UHF booster or distribution amp into the TV2 line if necessary. (EDIT: Booster/amp won't work if you're using the cable mode.)
Good luck with it and have a great weekend...!